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1994-09-24
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Document 0646
DOCN M9490646
TI Biology of disease and clinical aspects of AIDS-associated lymphoma: a
review.
DT 9411
AU Stein ME; Spencer D; Dansey R; Bezwoda WR; Northern Israel Oncology
Centre, Haifa.
SO East Afr Med J. 1994 Apr;71(4):219-22. Unique Identifier : AIDSLINE
MED/94341200
AB AIDS-related lymphoma was not apparent until 1985, when a statistically
significant increase in the frequency of lymphoma had occurred. Over 50%
are high-grade lymphoma, either immunoblastic or small, noncleaved cells
(Burkitt's-like lymphoma), with involvement of extranodal sites such as
the central nervous system (> one-third of patients), gastrointestinal
tract, skin and bone marrow. Optimal therapy for AIDS-associated
lymphoma has not yet been defined. Using intensive chemotherapy
protocols, high response rates, albeit of brief duration, have been
demonstrated. The majority of patients succumbed to intercurrent
opportunistic infections. Poor prognosis has been particularly noted in
debilitated patients, patients with a CD4 cell count of < 200/dl, bone
marrow and brain involvement and a history of AIDS before diagnosing the
lymphoma. New strategies in the management of patients with
AIDS-lymphoma should include cytotoxic therapy, antiretroviral therapy,
anti-pneumocystic Carini pneumonia, prophylaxis of CNS spread and marrow
protective therapy (haematopoietic growth factors).
DE Antineoplastic Agents/THERAPEUTIC USE Antiviral Agents/THERAPEUTIC USE
AIDS-Related Opportunistic Infections/*ETIOLOGY/MORTALITY Cause of
Death Drug Therapy, Combination Human *HIV-1 *Lymphoma,
AIDS-Related/BLOOD/DIAGNOSIS/EPIDEMIOLOGY/ETIOLOGY/ THERAPY Prognosis
Risk Factors Survival Rate JOURNAL ARTICLE REVIEW REVIEW, TUTORIAL
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).